Abstract

Paracoccidioidomycosis (PCM) is a deep mycosis characterized by mucocutaneous lesions, lymphadenopathy, and pulmonary involvement caused by Paracoccidioides brasiliensis , which mainly affects the skin, lymph nodes, lungs, and oral, nasal, and gastrointestinal mucous membranes. The main clinical differential diagnosis of oral and laryngeal mucous membrane lesions is cancer (i.e., squamous cell carcinoma). Depending on the specific immunity of the host, the infection can assume many forms and to affect multiple organs, and can eventually become a severe or fatal disease. In this paper, we highlight the important aspects for the differentiation of infectious diseases such as PCM and malignant neoplasm.

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