Abstract
Oral papillary squamous cell carcinoma (PSCC) presents as mixed white and red exophytic lesion involving the gingiva or alveolar ridges. The aim of this study is to report a papillary variant of squamous cell carcinoma mimicking an infectious disease. A 44-year-old female patient was referred for evaluation of painful gingival lesion of 2 years’ duration. Intra-oral examination revealed an extensive papillary plaque located on the vestibular and palatine gingiva, alveolar ridge, and hard palate from the teeth 17 to 23. Nasal mucosa also presented similar lesion. Computed tomography showed bone erosion of the alveolar process. The diagnosis hypotheses were infectious diseases and SCC. Biopsy showed extensive exophytic papillary epithelial cells with stromal microinvasion and nuclear atypia. Special staining excluded any infectious diseases. Treatment consisted of surgery and radiotherapy. This case presents an atypical variant of SCC, which should be considered in the differential diagnosis of papillary gingival lesions.
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