Oral Misoprostol Solution for Induction of Labour.

Abstract

To determine the effects of oral misoprostol solution for induction of labour. This is a prospective observational study. This study was conducted in Government Medical College, Aurangabad. Patients undergoing induction of labour after 36weeks of pregnancy were allocated by randomization to induction of labour with oral misoprostol solution administered 2h apart. Delivery within 24h after induction with oral misoprostol solution was the primary outcome on which the sample size was based. The data were analysed by Statistical Software for Social Sciences software. Two hundred patients were randomly selected for induction with oral misoprostol solution. There were no significant differences in substantive outcomes. Vaginal delivery within 24h was achieved in 80.5% of patients. The caesarean section rate was 19.5%. Uterine hyperactivity occurred in 4% of patients. The response to induction of labour in women with unfavourable cervices (modified Bishop's score <2) was somewhat slower with misoprostol, induction to delivery interval was more, oxytocin requirement was more, and vaginal delivery rate was less. This new approach to oral misoprostol solution administration was successful in achieving vaginal delivery rate in 24h in 80.5% of patients; rate of LSCS was less 19.5%.