ORAL MICROBIOME SEQUENCING TEST IN A CLINICAL CASE OF ACUTE MYELOID LEUKEMIA WITH PERSISTENT ORAL INFECTION

Abstract

A previously healthy, 45-year-old female patient, with the recurrence of acute myeloid leukemia, was hospitalized for oncological treatment. During hospitalization, she presented episodes of febrile neutropenia associated with pharyngotonsillitis and thrombocytopenia. Oral clinical examination presented erythematous and swollen gums with active bleeding. Thus, mechanical and chemical local control of the oral microbiota and systemic antibiotic therapy were instituted. Three conclusive cultures of gingival secretion were performed, which was conclusive for normal oropharyngeal microbiota; however, the infection panorama is still persistent. An oral microbiome DNA from saliva test was performed, resulting in 167027 sequences harboring 34 types of bacteria. Among the identified microorganisms, Granulicatella adiacens and Veillonella parvula were found in greater quantity, which could be responsible for oral homeostasis instability. Two days after the oral microbiome test result, the patient died. A previously healthy, 45-year-old female patient, with the recurrence of acute myeloid leukemia, was hospitalized for oncological treatment. During hospitalization, she presented episodes of febrile neutropenia associated with pharyngotonsillitis and thrombocytopenia. Oral clinical examination presented erythematous and swollen gums with active bleeding. Thus, mechanical and chemical local control of the oral microbiota and systemic antibiotic therapy were instituted. Three conclusive cultures of gingival secretion were performed, which was conclusive for normal oropharyngeal microbiota; however, the infection panorama is still persistent. An oral microbiome DNA from saliva test was performed, resulting in 167027 sequences harboring 34 types of bacteria. Among the identified microorganisms, Granulicatella adiacens and Veillonella parvula were found in greater quantity, which could be responsible for oral homeostasis instability. Two days after the oral microbiome test result, the patient died.