Oral microbiome research - a call for equity and inclusion.

Abstract

Over 700 oral bacterial species have been identified in human populations, with ~200 bacterial species identified in any given individual mouth. The relationship between the oral microbiome and health is evidenced in many studies, with dysbiosis (a shift from a healthy to less healthy state of microbial community) associated with dental caries, periodontitis, halitosis and oral cancer. However, oral microbiome research to date has focused primarily on European populations, particularly those in large urban centres housing academic institutions with access to research funding. Key anthropological perspectives examining the sociocultural, epidemiological, genetic and environmental factors that influence the oral microbiome have also been Euro-centric. Very little is known about how the oral microbiome mediates both oral and general disease risks specifically within Indigenous and other vulnerable populations. Undertaking oral microbiome research in under-served communities requires consideration of many issues often unfamiliar in the broader research community, including being acceptable, relevant and of perceived benefit to the communities being studied. Research materials need to be managed respectfully in a culturally safe way, sharing/translating the knowledge obtained. These approaches will likely provide unique insights into the complex connections between environment and biology, people and place, and culture and science in relation to the oral microbiome. The ongoing development of oral microbiome research must facilitate frameworks that are equitable and inclusive to better enable clinical and scientific expertise within marginalised communities.