Abstract
To the Editor.— I would like to respond to the letter "Oral Methadone Maintenance" by Dr. G. James Berry, which appeared in a recent issue ofThe Journal(220:1617, 1972). Over the past 2 1/2 years we have been involved in observing patients maintained with methadone hydrochloride in a clinic for this purpose. Although it is certainly true that a certain percentage of patients can and will be maintained with dosages as low as 30 mg/day (we have one who is taking 10 mg/day), we do not feel that the implication that most can be maintained with anything like this low dosage should gain credence. Many factors influence dosage, such as psychological situations, habits of previous abuse, fears concerning proper maintenance dosage, variations in perspiration rates, kinds of work, and intercurrent emotional states. In our observation, most of these patients require between 60 and 90 mg of methadone hydrochloride, with
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