Abstract
Primary hyperoxaluria (PH) is a rare disease, autosomal recessive inheritance disorder. This disease leads to overproduction of oxalates, and the excretation inability results in deposition of calcium oxalate crystals in almost all tissues presenting the oxalosis condition. The treatment is a combined liver and kidney transplantation (CLKT), which enables a better patient survival. Due to this survival, the patients had could present a several oral manifestations such as periodontal disease, root resorption, dental pain and increased tooth mobility. However, currently, there is a lack of information in the literature about all oral manifestations that this patient can present. Beside this, there are doubt and challenge about treatments to this patient in these different oral manifestations. The present study aims to report a case of a patient with hyperoxaluria type I with oxalosis oral manifestations.
Highlights
Primary hyperoxaluria (PH) is a rare inherited autosomal recessive disorder (Guerra et al 2014; Siegal et al 2011; Pijnenburg. et al 2017; Cochat&Rumsby, 2013)
Hyperoxaluria type II (PH2) has an oxalate overproduction caused by deficiency in glyoxylate reductase-hydroxypyruvate reductase (GRHPR) (Guerra et al 2014; Pijnenburg. et al 2017; Cochat&Rumsby, 2013) corresponding to 10% of Hiperoxaluria cases
Primary hyperoxaluria can occur at any age, until sixth decade of life, with an average age of 5.5 years. (Cochat & Rumsby, 2013; Lieske et al 2005) Renal disorder is the main manifestation that can lead to diagnosis, even so 10% of patients will only be diagnosed when the disease recurs after kidney transplantation
Summary
Primary hyperoxaluria (PH) is a rare inherited autosomal recessive disorder (Guerra et al 2014; Siegal et al 2011; Pijnenburg. et al 2017; Cochat&Rumsby, 2013). Oxalosis treatment with combined liver and kidney transplantation (CLKT) enables a better patient survival, which has caused an increase in the number of patients with oral hyperoxaluria lesions (Benmoussa et al 2015; Rinksma et al 2008). These patients need to be followed to diagnose these earlier manifestations and be encouraged to maintain good oral health to prevent periodontal diseases (Benmoussa et al 2015). Due to its rarity and impact on oral health, the present study aims to report a case of a patient with hyperoxaluria type I, with emphasis on the oral manifestations
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