Abstract
Crohn disease is an inflammatory chronic, relapsing, immune-mediated disorder of the gastrointestinal tract. Any part of the tract may be involved. We describe a case of a 45-year-old man with Crohn disease and hepatitis C virus genotype 1 a. Previous treatments kept him stable for 21 years. In December 2017, he developed mandibular vestibule ulcers, mucogingivitis, and cobblestones on the buccal mucosa. The patient took prednisolone 20 mg and infliximab, and biopsy of the buccal lesions revealed lymphoplasmacytic infiltration. He went through 4 photodynamic therapy sessions and 10 laser therapy sessions. He had short remission; however, 3 months later new linear ulcers, swelling, pain, and perianal lesions appeared. Microbiologic analysis taken from the oral mucosa did not reveal positive cultures. After these findings, drug treatment was changed, and the patient is currently in the first dose of ustekinumab, 40 mg of prednisone (Meticorten), laser therapy, and topical administration of clobetasol, already showing reduction of manifestations.
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