Abstract
Chronic graft-versus-host disease (GVHD) is a major late complication in patients treated by allogeneic hematopoietic stem cell transplantation. It is defined as a multisystem alloimmune and autoimmunelike disorder characterized by immune dysregulation, immune deficiency, impaired end-organ function, and decreased survival. Chronic GVHD resembles both clinically and histologically, many autoimmune disorders and other immunologic diseases. The oral cavity is the second most commonly involved organ system, behind skin involvement and can present as mucosal erythema, lichenoid lesions, ulcerated mucosa, and leukoplakia lesions that may be considered a potential risk factor for the development of oral cancer. We report the clinical features of 2 cases, occurring in a 41-year-old man and a 60-year-old woman. Both patients had a favorable outcome treated with topical or systemic corticosteroids and, in 1 of the cases, with the cyclosporine adjustment.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callMore From: Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology
Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
