Abstract
Involvement of the oral cavity in extranodal NK/T-cell lymphoma, nasal type (ENKTCL-NT) is uncommon and often presents as a palatal perforation. A 37-year-old male with ENKTCL-NT accompanied by palatal perforation was referred to our dental oncology service for evaluation of oral lesions at 1 month after radiation and chemotherapy. Intraoral examination revealed painful ulcers and pseudomembranes on the upper lip, bilateral buccal mucosa, and lateral border of the tongue. The main working diagnosis was oral mucositis. Treatment with low-level laser therapy, together with topical anesthetics and anti-inflammatory agents, produced no response. An incisional tongue biopsy was performed, and the results were consistent with a diagnosis of NK/T-cell lymphoma involvement. The patient presented a rapidly worsening clinical status and was admitted to the intensive care unit. This case underscores the aggressive behavior of this lymphoma and the atypical forms in which it can present.
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