Abstract
Malignant melanoma is a potentially aggressive tumor of melanocytic origin. Primary oral malignant melanoma (OMM) has a low prevalence, accounting for about 0.5% of all oral malignancies. This report is of an 80-year-old man who attended the stomatology clinic, reporting an increase in the volume of the lower lip since 6 months prior. Intraoral examination revealed a 2.5-cm pedunculated lesion, whitish in color, of friable surface in the right lower lip, and surrounded by irregular areas of brownish black pigmentation. The diagnostic hypothesis was squamous cell carcinoma and OMM. Incisional biopsy rendered a histopathologic diagnosis of malignant neoplasm of uncertain histogenesis. Immunohistochemically, the tumor cells were positive for S-100 protein and melan A and negative for CKAE1/AE3, p63, and CD31, yielding a diagnosis of OMM. The patient underwent lip shave surgery with tumor-free margins, and follow-up showed no signs of recurrence. Pigmented lesions in the oral cavity require great attention.
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