Oral Lichenoid Lesions Related to Drugs: Review of Clinicopathological Features and Differantional Diagnosis

Abstract

Izmir, Turkey; Department of Internal Medicine, Clinic of Rheumatology, Izmir Katip Celebi University Ataturk Training and Research Hospital, Izmir, Turkey Objective: Sjogren’s Syndrome (SS) is a systemic, multi-organ, autoimmune disease with an incidence of 4/ 100.000, predominantly affecting women. Minor salivary gland biopsy has been long considered as the gold standard of diagnosis. More than one focus (a cluster of >1⁄450 lymphocytes) within a 4mm area of glandular tissue is supportive for SS. Our study aims to demonstrate whether there is a significant difference between histologic focus score (FS)1⁄41 and FS>1. Study Design: Biopsies of 99 patients who were evaluated according to the American-European Consensus Group 2002 criteria (AECGC) at our instution’s Rheumatology clinic between 2010 and 2012 were reviewed retrospectively. Results: 91.9% of our patients were women. Two patients had inadequate samples for focus scoring. Out of 97 patients, 5 (5,15%) had FS1⁄41 and 32 (32.98%) FS>1. Chi-Square analyses showed a significant correlation between FS>1⁄41 and clinical presence of SS (p<0.004). Conclusions: FS1⁄41 was accepted, followed and treated as SS depending on AECGC.