Abstract
ABSTRACTChronic infection by hepatitis C virus (HCV) can lead not only to the development of hepatic cirrhosis, but also to the emergence of extra-hepatic manifestations (EHMs), such as oral lichen planus (OLP). Here, we describe a clinical presentation of massive, erosive OLP in an HCV-positive patient whose clinical management was difficult. Full remission was achieved after sustained virological response by using direct-acting anti-retrovirals. This case report demonstrates not only the importance of diagnosing EHMs for identification of HCV infection, but also the importance of controlling it for management of OLP and EHMs.
Highlights
The infection by hepatitis C virus (HCV) has a characteristic immunological component in which there is a progressive loss of regulatory control over inflammation and increasing release of proinflammatory cytokines capable of leading to the destruction of hepatic parenchyma.[1,2]Persistent immune activation and systemic inflammation have an impact on the progression of hepatic disease and development of extra-hepatic manifestations (EHMs) involving kidneys, eyes, musculoskeletal system, nervous system, skin and mucosas.[3]
When HCV infection is the cause of hepatic dysfunction, there is a triggering of systemic inflammatory reactions with deregulation of the patient’s immune response, which leads to the emergence of EHMs
In the present case report, the presence of oral lesions led us to perform a further investigation, which resulted in the diagnosis of chronic C hepatitis
Summary
Tenório[1 ], Alessandra Rodrigues de Camargo[2 ], Celso Lemos[3 ], Karem L. How to cite: Tenório JR, Camargo AR, Lemos C, Ortega KL.
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