Oral Intake of Hydrangea serrata (Thunb.) Ser. Leaves Extract Improves Wrinkles, Hydration, Elasticity, Texture, and Roughness in Human Skin: A Randomized, Double-Blind, Placebo-Controlled Study.

Da-Bin Myung,Yu-Kyong Shin,Jeong-Hun Lee,Eunjung Song,Sun Hee Lee,Kyung-Tae Lee,Hee-Soo Han,Hye Shin Ahn,Bo-Hyung Kim,Kwang-Young Lee,Kwang Hoon Lee

doi:10.3390/nu12061588

Abstract

Previously, we reported that the hot water extract of Hydrangea serrata leaves (WHS) and its active component, hydrangenol, possess in vitro and in vivo effects on skin wrinkles and moisturization. We conducted a randomized, double-blind, placebo-controlled trial to clinically evaluate the effect of WHS on human skin. Participants (n = 151) were randomly assigned to receive either WHS 300 mg, WHS 600 mg, or placebo, once daily for 12 weeks. Skin wrinkle, hydration, elasticity, texture, and roughness parameters were assessed at baseline and after 4, 8, and 12 weeks. Compared to the placebo, skin wrinkles were significantly reduced in both WHS groups after 8 and 12 weeks. In both WHS groups, five parameters (R1–R5) of skin wrinkles significantly improved and skin hydration was significantly enhanced when compared to the placebo group after 12 weeks. Compared with the placebo, three parameters of skin elasticity, including overall elasticity (R2), net elasticity (R5), and ratio of elastic recovery to total deformation (R7), improved after 12 weeks of oral WHS (600 mg) administration. Changes in skin texture and roughness were significantly reduced in both WHS groups. No WHS-related adverse reactions were reported. Hence, WHS could be used as a health supplement for skin anti-aging.

Highlights

Skin aging is divided into intrinsic aging and extrinsic aging
We previously reported that hydrangenol, a dihydroisocoumarin, possesses potential protective effects on cell viability, production of procollagen type I, matrix metallopeptidases (MMPs)-1, and pro-inflammatory cytokines [7]
The dried leaves of H. serrata were extracted with distilled water at 98 ◦ C for 5 h followed by filtration and spray-dried to give a dried extract residue water extract of Hydrangea serrata leaves (WHS) with a yield of 23% (w/w), which contained 7.7 mg/g of hydrangenol as the bioactive compound

Summary

Introduction

Skin aging is divided into intrinsic aging and extrinsic aging (photoaging). The clinical characteristics of intrinsic aging are relatively minor, such as fine wrinkles, dry skin, and reduced elasticity. Extrinsic aging causes thick and deep wrinkles when compared to intrinsic aging, and in severe cases increases skin dryness, reduces elasticity, and causes pigmental disorders and skin tumours [1]. Photoaging reduces the synthesis of collagen I and collagen III, the main constituents of the dermis, by inhibiting transforming growth factor (TGF)-β and TGF-α by activating the activator protein 1 (AP-1), as well as nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB). These transcription factors promote the decomposition of intracellular tissue by activating matrix metallopeptidases (MMPs), especially MMP-1, MMP-3, and MMP-9. The keratin layer of the healthy epidermis contains 15–20% water, and if the water drops below 10%, the skin will get dehydrated, and the wrinkles will increase as it loses its gloss and elasticity

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