Abstract
Collagen peptide (CP) has beneficial effects on functions of the skin, such as skin barrier function and skin elasticity, in vivo. However, there are few studies investigating the mechanism underlying the potential effects of CP in skin epidermal moisturization after ultraviolet B (UVB) irradiation. In this study, we examined whether orally-administered CP affects the loss of skin hydration induced by UVB irradiation in hairless mice. SKH-1 hairless mice were orally administered CP at two doses (500 and 1000 mg/kg) for nine weeks, and the dorsal skin was exposed to UVB. The potential effects of CP were evaluated by measuring the transepidermal water loss (TEWL), skin hydration, wrinkle formation, and hyaluronic acid expression in the dorsal mice skin. We found that oral administration of CP increased skin hydration and decreased wrinkle formation compared to the UVB-irradiated group. Treatment of CP increased the mRNA and protein expression of hyaluronic acid synthases (HAS-1 and -2) concomitant with an increased hyaluronic acid production in skin tissue. The expression of hyaluronidase (HYAL-1 and 2) mRNA was downregulated in the CP-treated group. In addition, the protein expression of skin-hydrating factors, filaggrin and involucrin, was upregulated via oral administration of CP. In summary, these results show that oral administration of CP increases hyaluronic acid levels, which decreases during UVB photoaging. Therefore, we suggest that CP can be used as a nutricosmetic ingredient with potential effects on UVB-induced skin dehydration and moisture loss in addition to wrinkle formation.
Highlights
Repetitive exposure to ultraviolet radiations (UVRs) leads to various skin disorders including inflammation, aging, and cancer [1]
Changes in Transepidermal Water Loss, Skin Hydration, and Epidermal Thickness in the Skin of Hairless Mice Treated with Collagen Peptide
Basal transepidermal water loss (TEWL) and stratum corneum hydration were measured to investigate the effects of Collagen peptide (CP) on epidermal barrier function
Summary
Repetitive exposure to ultraviolet radiations (UVRs) leads to various skin disorders including inflammation, aging, and cancer [1]. Oral supplementation with food ingredients including vitamins and antioxidants, fatty acids, and hydrolyzed proteins helps improve skin functions damaged by overexposure of UVB [5]. This trend is observed across all nutricosmetics key industries. CPs have been reported to be beneficial for skin dysfunction in UVB-induced skin aging models [16]. There is evidence for the beneficial effects of CPs on UVB irradiation-induced skin dysfunction in humans or animals, the effect of CP on skin hydration and the underlying mechanisms are poorly understood. To determine the skin-hydration and anti-wrinkle effects of oral treatment with CP, we investigated its activities and mechanisms in UVB-irradiated SKH-1 hairless mice skin models
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