Oral intake of collagen hydrolysate from mackerel scad (Decapterus macarellus) attenuates skin photoaging by suppressing the UVB-induced expression of MMP-1 and IL-6.

Abstract

Excessive skin exposure to UVB radiation can induce photoaging caused by an imbalance in oxidative stress and inflammatory responses, damaging the skin's structure and surface layer. A previous study revealed that collagen hydrolisate extracted from the skin of mackarel scads (Decapterus macarellus) had antiaging properties thatwere tested invitro, which serves as a foundation for asubsequent study of its use invivo. This study aimed at investigating the repair effect of the mackerel scad's skin collagen hydrolysate (MSS-CH) in photoaging conditions in amouse model. MSS-CH was given orally in mice model of skin photoaging under chronic exposure to UVB irradiation for12weeks. Morphological and histological changes on the skin were evaluated using SEM and HE staining, along withthe measurement of the expression of matrix metalloproteinases (MMP-1) and cytokine pro-inflammatory interleukin 6 (IL-6) using ELISA. MSS-CH inhibits the occurrence of epidermal thickening and damage to the dermal layer of the skin. As aresult, it restores the epidermis' barrier function and reduces surface damage caused by photoaging. The skin ofthe MSS-CH treated group exhibited improved physical appearance with reduced fine lines, wrinkles, and enhanced smoothness. Additionally, administering MSS-CH to the mice groups reduced the expression of MMP-1 and IL-6 in UVB-exposed skin. Altogether, this invivo study demonstrates thephotoaging-protective properties of CH-MSS, aligning with previous invitro data. Thus, MSS-CH emerges as a strong candidate for use as an ingredient in nutraceuticals and biocosmetics.