Abstract
Food avoidance is still considered the gold-standard treatment for food allergy (FA). However, recently it has been consolidating the theory that, where possible, the food intake might facilitate the induction of desensitization and tolerance, resulting more effective and safer -if we consider the possibility of accidental ingestion- than a strict avoidance diet [1]. Furthermore, specific oral immunotherapy (OIT) is the unique active treatment for IgE-mediated FAs [1].
Highlights
Food avoidance is still considered the gold-standard treatment for food allergy (FA)
Recent data have shown that a key role in the induction of tolerance by oral immunotherapy (OIT) is played by a subgroup of regulatory T cells known as “induced T reg” [6,7]
Changes in the DNA of induced T reg” (iTreg) - specific antigen may predict the development of a state of clinical immune tolerance during OIT [8]
Summary
Food avoidance is still considered the gold-standard treatment for food allergy (FA). Specific oral immunotherapy (OIT) is the unique active treatment for IgE-mediated FAs [1]. Efficacy Studies have shown short-term efficacy: namely theOITability to induce desensitization (loss of responsiveness to food-antigen during continuous assumption of OITdoses) [2,3,4,5].
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