Abstract
Objective: The condition of the resected margin in oral squamous cell carcinoma continues to be an importantprognostic factor; the use of optic technology could help surgeons in determining the margin status at real time.This study aims to evaluate Oral ID, a hand held device that uses the principal of auto-fluorescence to determinesurgical safe margins in patients with oral squamous cell carcinoma, and to compare the results with those of theconventional 1 cm margin method. Material and Methods: This study was a descriptive, comparative analyticalstudy carried out at Khartoum Dental Teaching Hospital and Oral Histopathology Diagnostic Laboratory, Facultyof Dentistry, University of Khartoum. A total of 92 margins obtained from 31 patients, 46 margins were taken byOral ID and the other 46 were taken by the traditional 1cm method. All margins were examined histologicallywith conventional Hematoxylin and Eosin stain. Results: It was found that all tumors showed fluorescence loss; Asignificant association was found between the use of Oral ID and obtaining a free margin P (0.02) the sensitivityof Oral ID was found to be 74% the specificity was found to be 89%. Ten out of the 46 margins obtained byfluorescence showed mild dysplasia and two margins showed high grade dysplasia. The 46 margins obtainedby the traditional 1cm margin showed different field alterations two were involved, one was close, five showedhigh grade dysplasia and 14 showed mild dysplasia yielding a specificity of 52.2%. Conclusion: Using Oral IDfor surgical margin assessment increases the accuracy to 74% compared to the conventional method which wasfound to be 52.2%. The results of the device are comparable to other auto-fluorescence devices of differenttrademarks. Further development of the device to help overcome its limitations is strongly advised. KEYWORDSOral ID; Auto-fluorescence; Cancer; Diagnosis; Oral squamous cell carcinoma.
Highlights
Oral cancer is a major public health problem both in the Sudan and worldwide
During a period of two years 31 patients diagnosed with oral squamous cell carcinoma attending Khartoum Dental Teaching Hospital were included in this study. 58% of the participants were male with a mean age of 54 (Figures 1 and 2)
Oral ID® as an adjunctive tool for surgical margin assessment OraiIlDn®aspanadtjuiencntivtetsoowflorsiutrghicaoml raarglinassqesusmaemntinopautisentcsweitlhloracslaquracminouoscmeclarc:inaomcaa:ocommpaarartivaesttuivdey study differentiated (12.9%) with no previous history of chemotherapy and radiotherapy patients with recurrent disease were excluded from the study (Figure 3). 58% of the patients participating in the study were males with a mean age of 54 the most common affected sites were the tongue, the buccal mucosa and the gingiva which all showed an equal percentage of incidence at 25.8% (Figure 4)
Summary
Oral cancer is a major public health problem both in the Sudan and worldwide. Of all oral neoplasms squamous cell carcinoma is one of the most frequent tumors affecting the oral cavity. Recent studies have shown that more than 90% of malignant neoplasms affecting the oral cavity are of squamous cell carcinoma type [1,2]. The use of a local snuff “Toombak ”and infection by HPV have shown to be the major causes of oral and orophararyngeal cancer in the Sudan [3,4,5]. The gold standard for the treatment of oral squamous cell carcinoma (OSCC) remains surgical excision with tumor free margins. It exposes the patient to the hazards and complications of a second surgery or adjunctive therapy such as radiotherapy and chemotherapy, adding the burden of post therapeutic complications and extra cost on the patient
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
