Abstract
Hyaluronan (HA) is present in all connective tissues and organs, including the skin and joint fluid. However, few clinical trials have comprehensively evaluated the impacts of oral HA on skin conditions, including wrinkles and moisturization. In this study, we conducted a placebo-controlled, randomized, double-blind trial of daily HA (120 mg) intake for 12 weeks in 40 healthy Asian men and women (aged 35–64 years). Skin condition was determined by the evaluation of wrinkles, stratum corneum water content, the amount of transepidermal water loss, elasticity, and through image analysis. After 12 weeks, skin condition was significantly improved in terms of wrinkle assessment, stratum corneum water content, transepidermal water loss, and elasticity in the HA group compared to the placebo group. Regarding the percentage change from baseline, wrinkle assessment, stratum corneum water content, and skin elasticity were significantly improved in the HA group versus the placebo group after 8 and 12 weeks of ingestion. The present findings indicate that oral ingestion of HA may suppress wrinkles and improve skin condition.
Highlights
Christopher ChamcheuHyaluronan (HA) is synthesized in all animals and some microorganisms
There was no significant difference between the HA and placebo groups at week 0 (Table 1)
The assessment showed that the HA group had significantly higher stratum corneum water content in the facial measurement sites (p = 0.02) as compared with the placebo group at 12 weeks after ingestion
Summary
Hyaluronan (HA) is synthesized in all animals and some microorganisms. In vivo, it is present in all connective tissues and organs, including the skin, joint fluid, blood vessels, serum, the brain, cartilage, heart valves, and the umbilical cord. Surgical techniques (e.g., injection of HA fillers), topical agents, cosmetics, and health functional foods are currently utilized for the anti-aging treatment of the skin and improvement of dry skin. Oe et al reported that the administration of HA (120 mg/day) for 12 weeks in 50 Japanese men and women (aged 22–59 years) with wrinkles around their eyes resulted in a significant reduction in wrinkle volume ratio after 8 weeks of consumption versus the placebo (p < 0.05) [13]. We conducted a double-blind, randomized, placebo-controlled, parallel-group trial involving Asian men and women aged 35–64 years to evaluate the impacts of HA consumption on the skin, with a particular emphasis on multifaceted skin assessment
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