Abstract
Background: the genetic factor of type 1 diabetes mellitus may play a key role in pathogenesis of that disorder, thus, diabetic siblings might prone into an impaired OGTT. Objective: To determine whether diabetic Siblings might have an impaired glucose tolerance test in compare to normal control group. Methodology: A case-control study was performed on 120 persons, they divided into three group which are diabetic, siblings and control (40 persons in each group), who attended to Al Zahraa Teaching Hospital /Diabetic Center in Al-Kut between the period of April; 2012 till April; 2013. Results: OGTT performed on both diabetic siblings and control, results have showed that the Means of OGTT is highly Significant (P value = 0.000) in both Siblings and Control groups, whereas there were no Significant differences in the Means of differences of OGTT in both tested groups (Siblings and Control), P value = 0.288, although the Mean of differences of OGTT is higher in Siblings group (25.3250) than that in Control group (22.0750). Conclusion: the inheritance factor play a key role in pathogenesis of type 1 diabetes mellitus since, diabetic siblings showed an impaired OGTT. Recommendation: for early detection of diabetes, diabetic siblings must submit to a routine screening test by OGGT.
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