Abstract
We read with great interest the article by Rinella et al. [1] in which they evaluated the influence of insulin resistance on methionine–choline deficient (MCD) diet model of non-alcoholic steatohepatitis (NASH) in male FVB/NJ mice. Briefly, they fed the mice with MCD, MCD control and chow diet for 10 or 28 days, they performed glucose tolerance tests (GTT), insulin tolerance tests (ITT) and quantitative insulin sensitivity check index (QUICKI) to put forward the influence of insulin in the model, which is unknown. The MCD diet group showed evidence of increased insulin sensitivity in the GTT, ITT and QUICKI both at the 10th and 28th days of the diet. The data demonstrated that MCD diet fed mice do not exhibit any sign of insulin resistance compared to control groups.
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