Abstract
We read with great interest the article by Rinella et al. [1] in which they evaluated the influence of insulin resistance on methionine–choline deficient (MCD) diet model of non-alcoholic steatohepatitis (NASH) in male FVB/NJ mice. Briefly, they fed the mice with MCD, MCD control and chow diet for 10 or 28 days, they performed glucose tolerance tests (GTT), insulin tolerance tests (ITT) and quantitative insulin sensitivity check index (QUICKI) to put forward the influence of insulin in the model, which is unknown. The MCD diet group showed evidence of increased insulin sensitivity in the GTT, ITT and QUICKI both at the 10th and 28th days of the diet. The data demonstrated that MCD diet fed mice do not exhibit any sign of insulin resistance compared to control groups.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
