Abstract
Oral focal mucinosis (OFM) is a soft tissue lesion commonly characterized by swelling in the gingiva; its occurrence in the palatal mucosa is rare. Differential diagnosis of OFM includes mucocele, nerve sheath myxoma, and myxoma, and the histologic and immunohistochemical findings are important for diagnosis. A 62-year-old man presented with a nodular lesion on the hard palate; excisional biopsy was performed. The histopathologic examination revealed a loose, myxomatous connective tissue stroma, with ovoid, fusiform, or stellate-shaped fibroblasts. The stroma was positive for Alcian blue and negative for periodic acid–Schiff staining, indicating overproduction of hyaluronic acid. Immunohistochemical analysis demonstrated that spindle cells were negative for S-100, vimentin, and CD34. After surgical excision, the patient is under regular follow-up, and no recurrence has been observed. This case highlights the importance of immunohistochemical analysis to confirm the final diagnosis.
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