Abstract
The study illustrates the influence oral dosage form design has on dissolution rates for drugs from different chemical and pharmacological classes. Comparative data demonstrate that relatively insoluble drugs, when formulated in soft elastic capsules, are released faster than from commercially available tablets. Faster dissolution from soft elastic capsules is believed to be due to the more rapid dispersion of the active ingredients. Rapid dispersion of medicaments is enhanced by the use of solubilizers and/or surfactants in the formulation design. Soft elastic capsules are recommended for the formulation of low-dose medications, of relatively insoluble drugs, and of drugs where early high-blood level of the drug is indicated.
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