Abstract
Oral dissolving films (ODFs) are thin, flexible, and fast-dissolving sheets that can deliver active substances to the oral cavity. They offer several advantages over conventional oral dosage forms, such as ease of swallowing, precise dosing, improved patient compliance, and rapid onset of action. ODFs can be used for various therapeutic applications, such as anti-ulcer, anti-asthmatic, antihistamine, and analgesic drugs. This review article presents a comprehensive analysis of recent advancements in ODF formulation, manufacturing techniques, and their diverse applications in pharmaceutical, nutraceutical, and biomedical fields. The formulation of ODFs involves the selection of suitable polymers, plasticizers, surfactants, flavours, and sweeteners. The polymers are the main component that determines the mechanical properties, disintegration time, and drug release profile of the films. The plasticizers are added to improve the flexibility and elasticity of the films. The surfactants are used to enhance the solubility and permeability of the drugs. The flavours and sweeteners are used to mask the unpleasant taste of the drugs and improve the palatability of the films. The production methods of ODFs include solvent casting, hot melt extrusion, and roll casting. These methods differ in terms of the equipment, process parameters, and film quality. Each technique's advantages, limitations, and potential for scalability are outlined, providing insight into the critical factors influencing ODF development. In summary, this review article provides a comprehensive overview of the recent progress in ODF technology, encompassing formulation optimization, manufacturing advancements, and innovative applications. As the field of oral dissolving films continues to evolve, this article offers valuable insights for researchers, clinicians, and pharmaceutical industry stakeholders seeking to harness the full potential of this versatile drug delivery platform. Keywords: Oral dissolving films, Plasticizer, Solvent casting method, Hot melt extrusion, Roll casting
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