ORAL DISINTEGRANTING TABLETS: AN OVERVIEW

Abstract

Especially for patients who have dysphagia or difficulty swallowing, oral disintegrating tablets (ODTs) have developed as a novel dosage form to address a number of issues related to traditional solid dosage forms. An overview of the formulation techniques, assessment criteria, and uses of ODTs in pharmaceutical research are given in this study. In order to accomplish quick disintegration and dissolution of the tablet matrix upon contact with saliva, formulation processes such as sublimation, lyophilization, and direct compression have been thoroughly investigated. When evaluating the quality qualities of ODTs, evaluation metrics such as drug content homogeneity, hardness, friability, and disintegration time are essential. To improve patient acceptance and palatability, superdisintegrants and a variety of taste-masking techniques have been used. Furthermore, ODTs adaptability goes beyond traditional oral administration they may be used for emergency and travel medicine, as well as in paediatric and geriatric populations. All things considered, ODTs present a viable platform for enhancing patient convenience and compliance, which maximises therapeutic results. ODTs provide a number of benefits, such as improved patient compliance, simplicity of administration, and greater bioavailability because of their quick dissolving and larger surface area. To sum up, oral disintegrating tablets offer a potentially effective option for individuals who need readily administrable and comfortable dose forms. ODTs will be further optimised by ongoing research and development into manufacturing and formulation processes, increasing their applicability to a wider range of patient demographics and therapeutic areas.