Oral detergent exposure alters the esophageal microbiome and induces eosinophilic inflammation

Abstract

Detergent exposure is a possible environmental factor recently implicated in the pathogenesis of eosinophilic esophagitis (EoE). We have shown the detergent sodium dodecyl sulfate (SDS) induces epithelial barrier dysfunction and eosinophilic inflammation in mice. We aimed to examine changes in the mouse esophageal microbiome following SDS exposure.