Abstract
Abstract Introduction: Recent studies have pointing creatine supplementation as a promising therapeutic alterna- tive in several diseases, especially myopathies and neurodegenerative disorder. Objective: elucidate the role of creatine supplementation on deleterious effect caused by limb immobilization in humans and rats. Methods: Analyzed articles were searched by three online databases, PubMed, SportDicus e Scielo. After a review and analysis, the studies were included in this review articles on effect of creatine supplementation on skeletal muscle in humans and rat, before, during and after a period of limb immobilization. Results: Studies analyzed demonstrated positive points in use of creatine supplementation as a therapeutic tool to mitigating the deleterious effects of limb immobilization, in humans and rat. Conclusion: The dataset of this literature review allows us to conclude that creatine supplementation may reduce muscle loss and/or assist in the recovery of muscle atrophy caused by immobilization and disuse in rats and humans. Also, we note that further research with better methodological rigor is needed to clarify the mechanisms by which creatine support the recovery of muscle atrophy. Moreover, these effects are positive and promising in the field of muscle rehabilitation, especially after member’s immobilization.
Highlights
Recent studies have pointing creatine supplementation as a promising therapeutic alternative in several diseases, especially myopathies and neurodegenerative disorder
The main findings of this systematic review were: 1) creatine supplementation is able to mitigate the loss and / or assist in the recovery of muscle atrophy caused by immobilization and disuse in mice and humans; 2) start supplementation immediately with immobilization and / or the rehabilitation process are the main ways to achieve positive results; 3) numerous mechanisms have been linked to these beneficial effects, the exact mechanism by which creatine supplementation alleviates muscle atrophy caused by immobilization is still unknown
These results suggest that creatine supplementation may minimize changes in energy metabolism triggered by immobilization, a fact that possibly favors faster recovery after immobilization
Summary
Recent studies have pointing creatine supplementation as a promising therapeutic alternative in several diseases, especially myopathies and neurodegenerative disorder. Results: Studies analyzed demonstrated positive points in use of creatine supplementation as a therapeutic tool to mitigating the deleterious effects of limb immobilization, in humans and rat. We note that further research with better methodological rigor is needed to clarify the mechanisms by which creatine support the recovery of muscle atrophy These effects are positive and promising in the field of muscle rehabilitation, especially after member’s immobilization. The reduction of these stimuli may result in exaggerated amount of calcium in the sarcoplasmic reticulum, leading to modify the feedback mechanism that determines the changes in the motor cortex reception (4 – 7) In view of this scenario, the use of creatine supplementation is a strategy that has been adopted to alleviate muscle disorders (8 – 11)
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