Abstract
Background : The efficacy of oral indomethacin/ ibuprofen in the closure of hemodynamically significant PDA is not extensively studied. Aim : Retrospective analysis of data on the efficacy and safety of oral cyclooxygenase (COX) inhibitors- indomethacin and ibuprofen in patent ductus arteriosus (PDA) closure. Materials and methods : All preterm (28-36.6weeks) infants born between July 2011- June 2012 who received oral cyclooxygenase inhibitors for closure of PDA were included in the study. The outcome measured was closure rate of PDA. Results : Of the 162 preterm neonates, 34 received oral COX inhibitors. Of them 27 received oral indomethacin and 7 received syrup ibuprofen. The total closure rate was 91.2% after first course and 8.8% of neonates required a second course with complete closure. No neonate required surgical closure. In the indomethacin group, 5 patients had thrombocytopenia and 1 had NEC. However, none of the cases in ibuprofen group had any significant side effects. Conclusion : Oral COX inhibitors are an effective therapy for closure of PDA.
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