Abstract
IN A CASE previously reported by us,<sup>1</sup>pulmonary infarction occurred in a patient who had sicklethalassemia disease and was taking an oral contraceptive. During pregnancy, the patient had a similar episode. Oral contraceptives, while not primary agents in intravascular coagulation, may cause thromboembolism in women with predisposing conditions.<sup>2</sup>We have not seen a report documenting the concurrence of thrombosis, sickle cell hemoglobinopathy, and the use of oral contraceptives. Two additional cases noted here suggest that sickle cell hemoglobinopathies may be a contraindication to the administration of the contraceptive drugs. <h3>Report of Cases</h3><h3>CASE 1.—</h3> A 26-year-old, gravida 3, para 3, Negro woman with sickle cell—hemoglobin C disease had had no thromboembolic episode until the eighth month of use of an oral contraceptive (norethynodrel with mestranol [Enovid] 5 mg daily), when she experienced sudden fever, chest pain, and a cough. She was hospitalized, and a diagnosis of pneumonitis with
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