Abstract
Prospective clinical studies with oral contraceptives and retrospective case control studies are reviewed. The author presents evidence that prospective clinical studies with oral contraceptives do not demonstrate an increased incidence of superficial or deep vein thromboembolic disease thus failing to confirm the hypothesis of an association derived from the retrospective case control studies. Basically the retrospective case control approach does not measure the incidence of disease but supplies data regarding association whereas in prospective clinical studies the incidence of disease is determined. The author notes that the incidence of thromboembolic disease is not increased in the antenatal patient. He also states that a recently published retrospective study of stroke which makes a theoretical projection of a risk based on the hypothesis of association is not supported by other studies making a more direct measurement.
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