Abstract
In order to investigate the effect of various hormonal influences and antifertility compounds on chemically induced carcinoma of the cervix uteri in mice 910-dimethyl-1-12-benzanthracene (DMBA) treated animals received subcutaneous implantations containing the active agent (progesterone 25 mg testosterone propionate 10 mg chlormadinone acetate 5 mg quingestanol acetate 2.5 mg norethisterone acetate 5 mg and ethingl estradiol 1.25 2.5 5 and 10 mg) and cholesterol. Ethinyl estradiol acted as a strong promoter of DMBA-induced carcinogenesis in mice. Fewer progesterone-treated animals developed carcinoma than the controls. It is felt that the composition of oral contraceptives should be guided in the direction of using progestational compounds only. Exclusion of the synthetic estrogen may possibly reduce the existing fear of cancer development.
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