Abstract
We find no reason to feel that norethindrone and norethindrone acetate with or without ethinyl estradiol produces deleterious metabolic effects when administered continuously for as long as 6 years. The capsules of an ovary removed from each of 3 women treated for 46 to 62.5 cycles each appeared thickened with fibrotic change. The incidence of carcinoma in situ among treated patients has not varied appreciably from the norm for this community. The average effort time for conception subsequent to administration of the above-mentioned drugs for nearly 3.5 years or less was 6.5 months with a range of 1 to 42 months.Some isolated experiences with thrombophlebitis complicating treatment and treatment being administered concomitant with the occurrence of thrombophlebitis are included.
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