Oral contraceptive-induced hepatic sinusoidal dilatation

Abstract

A 39-year-old female who had been on oral contraceptive treatent (OCP) for several years presented with abnormal liver tests AST 44 U/L, ALT 49 U/L, ALP 312 U/L, total bilirubin 17.0 mol/L). he had no prior medical history and was taking no other medcations or supplements. Chronic liver disease serologies were egative. Ultrasonography with Doppler analysis revealed mild epatomegaly and normal hepatic vasculature. Magnetic resoance imaging (MRI) revealed hepatomegaly and post-gadolinium cans demonstrated heterogeneous enhancement, more promient in the periphery of the liver. Liver biopsy showed prominent entrilobular sinusoidal dilatation with accompanying hepatoyte atrophy (Fig. 1) and mild peri-sinusoidal fibrosis without vidence of portal or lobular inflammation, ductular changes or teatosis (Fig. 2). The clinical significance of sinusoidal dilatation