Oral Chelation Therapy for Cadmium Poisoning with Cd(II)-Mac Imprinted pHEMAC Nanoparticles

Abstract

In this study was prepared Cd(II)) ion-imprinted poly(hydroxyethyl methacrylate-N-methacryloyl-(L)-cysteine methylester) pHEMAC nanoparticles for the oral treatment of heavy metal poisoning. Cd(II) ion-imprinted pHEMAC nanoparticles were characterized by TEM, FTIR, zetasizer, and surface area calculations. The efficiency and selectivity of these Cd(II) ion imprinted pHEMAC nanoparticles were investigated both in deionized water and simulated gastrointestinal fluids. Adsorption studies were performed at different pH, temperature and initial concentrations of Cd(II) ion to determine optimum conditions. The selectivity studies were accomplished with Cd(II) ion imprinted and non-imprinted pHEMAC nanoparticles by using different metal ion solutions (i.e., copper, zinc, nickel, and lead). Langmuir and Freundlich isotherms were applied for these adsorption studies