Abstract
Cellular neurothekeoma is known as a cutaneous tumor with uncertain histogenesis. Very little involvement of mucosal membrane has been reported in the literature so far. This is a case report of an intraoral lesion in a 15-years-old girl. Histopathologic evaluation showed a tumor-consists of spindle to epitheloid cells forming micronodules in a concentric whorled shape pattern. Tumor cells were positive for CD63, vimentin, and NKI-C3. Total excision was performed and no recurrence happened after 16-month followup.
Highlights
Neurothekeoma (NTK) is a generally accepted term for a rare type of benign dermal tumours originating from nerve sheath, first proposed by Gallager and Helwig in 1980 [1]
The patient had no other signs or symptoms. Her past medical history included acute lymphoblastic leukemia (ALL), diagnosed at the age of 2 years requiring irradiation followed by bone marrow transplant
Clinical differential diagnoses that we had in mind before biopsy for such lesion in a patient with a history of ALL were more common possibilities including lymphoma, minor salivary gland tumors, and granular cell tumor
Summary
Neurothekeoma (NTK) is a generally accepted term for a rare type of benign dermal tumours originating from nerve sheath, first proposed by Gallager and Helwig in 1980 [1]. This entity was previously described and known as nerve sheath myxoma. Cellular NTK was later identified as a subtype based on histopathological and immunohistological features [2, 3] It is generally a cutaneous lesion, and mucosal involvement has been rarely reported. These numbers are even less in case of cellular variant [4]. This is a report of a cellular neurothekeoma of the oral cavity in a 15-years-old girl
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