Oral cavity and a second primary cancer in the larynx

Abstract

Head and neck cancer represents the sixth most common cancer in the world. Men are affected two to three times more than women, possibly as a result of higher tobacco and alcohol consumption. Oral cavity tumors have the highest rate of developing second primary malignancies. In patients with malignancies associated with alcohol and tobacco consumption, 80% of second primary tumors appear in the oral cavity, oropharynx, and larynx. Second primary tumors are usually invasive in nature with early metastasis and should be treated with aggressive therapy. Herein, we report a rare case of a second primary cancer in the larynx after a gingival squamous cell carcinoma.