Abstract
Background: Oral candidiasis is by far the most common oral fungal infection in humans. It is caused by the fungal organism Candida albicans. When the host is debilitated by other diseases and conditions, C. albicans, which is usually a part of the normal oral flora, can turn pathogenic and invade the host tissue to cause the infection. The purpose of this paper is to investigate the role of systemic diseases and medications in the development of oral candidiasis.Methods: A total of 12 cases with code indicating oral candidiasis were collected from the University of Pittsburgh School of Dental Medicine Dental Registry and DNA Repository. The systemic diseases and medications were descriptively analyzed.Results: 50% of the subjects had more than two systemic diseases. The most prevalent diseases were mental illnesses (50%), cardiovascular diseases (41.7%), and respiratory system diseases (33.3%). 50% of subjects were on polypharmacy therapies and 75% of subjects were taking medications that may contribute to oral candidiasis. Among the medications, antidepressants and inhalational corticosteroids may have strong potentials to cause oral candidiasis.Conclusion: Oral candidiasis is associated with having systemic diseases and intake of medication, especially with those medications can cause xerostomia. As the number of systemic diseases and medications increases, the risk of developing oral candidiasis may increase too.
Highlights
Candidiasis is by far the most common oral fungal infec-‐ tion in humans and has a variety of clinical manifestations
[1] C. albicans is considered as part of the normal oral flora and the prevalence of oral Can-‐ dida carriage in the healthy popu-‐ lation has been estimated to range from 23% to 68%
50% of the study samples were having three or more than three systemic dis-‐ eases, which is in agreement with previous observations suggesting that having multiple systemic dis-‐ eases and medical conditions is associated with oral candidiasis
Summary
Candidiasis is by far the most common oral fungal infec-‐ tion in humans and has a variety of clinical manifestations. It is the infection caused by the yeast-‐like fungal organism Candida albicans. Oral candidiasis is by far the most common oral fungal infec!on in humans It is caused by the fungal or-‐ ganism Candida albicans. When the host is debilitated by other diseases and condi!ons, C. albicans, which is usually a part of the normal oral flora, can turn pathogenic and invade the host 2ssue to cause the infec2on. The purpose of this paper is to inves-gate the role of systemic diseases and medica-ons in the development of oral candidiasis. As the number of systemic diseases and medica!ons increases, the risk of developing oral candidiasis may increase too
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