Abstract
High-grade B-cell lymphomas (HGBLs) are aggressive B-cell neoplasms also known as double-hit and triple-hit lymphomas, that harbor translocations in BCL2, BCL6, and/or MYC genes. This study describes the clinicopathologic data, immunohistochemical features, EBV status, and molecular findings of 8 cases of HGBLs that were retrieved from the files of 3 oral pathology centers from 2001 to 2019. The median age at presentation was 64.4 years without sex predominance. Most cases involved the oral cavity as asymptomatic swellings. Microscopically, the tumors exhibited a diffuse growth pattern, mostly composed of large centroblasts. Three cases showed the starry sky appearance. Most cases were positive for Bcl2, MUM1, Bcl6, and c-Myc proteins. The mean proliferative index was 74.5%. Double translocations of MYC/BCL2 and MYC/BCL6 genes were observed in 3 and 2 cases, respectively. Three cases demonstrated simultaneous rearrangements of MYC/BCL2/BCL6. HGBL can be found in the oral/oropharyngeal region and is associated with aggressive clinical presentation. High-grade B-cell lymphomas (HGBLs) are aggressive B-cell neoplasms also known as double-hit and triple-hit lymphomas, that harbor translocations in BCL2, BCL6, and/or MYC genes. This study describes the clinicopathologic data, immunohistochemical features, EBV status, and molecular findings of 8 cases of HGBLs that were retrieved from the files of 3 oral pathology centers from 2001 to 2019. The median age at presentation was 64.4 years without sex predominance. Most cases involved the oral cavity as asymptomatic swellings. Microscopically, the tumors exhibited a diffuse growth pattern, mostly composed of large centroblasts. Three cases showed the starry sky appearance. Most cases were positive for Bcl2, MUM1, Bcl6, and c-Myc proteins. The mean proliferative index was 74.5%. Double translocations of MYC/BCL2 and MYC/BCL6 genes were observed in 3 and 2 cases, respectively. Three cases demonstrated simultaneous rearrangements of MYC/BCL2/BCL6. HGBL can be found in the oral/oropharyngeal region and is associated with aggressive clinical presentation.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callMore From: Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology
Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
