Oral And Facial Lesions of Blue Rubber Bleb Nevus Syndrome: Case Report

Abstract

Blue rubber bleb nevus syndrome (BRBNS) is a rare disease first described in 1860 that usually presents as cavernous hemangiomas of the skin and gastrointestinal (GI) tract. Cutaneous lesions are characterized by multiple, compressible, protuberant dark blue blebs. GI findings may develop from the oral to the anal mucosa; severe bleeding is the most important complication of this disease. Cerebrovenous malformation, skeletal bowing, articular pain, and cardiac hypertrophy have also been described. Facial and intraoral lesions are not rare. Previous reports showed about 50% of cases with dark blue blebs and/or cavernous hemangiomas. Man, 65, was referred for oral investigations. We founded lesions on his neck, eyelid, lip, and tongue. The differential diagnoses and management of oral mucosal lesions are discussed.