Abstract
The 24 day LD/sub 50/ of monosodium methanearsonate (MSMA) for New Zealand white rabbits was estimated to be 102 mg MSMA/kg body weight. The average size of the rabbit dermal irritant patch tests was 1.0, indicating that MSMA is a mild irritant to intact skin. Relatively little work has been done on the toxicity of organic arsenicals, especially the herbicide monosodium methanearsonate (MSMA). The EPA review reported a dermal study carried out on 6 adult male rabbits. The clipped skin areas of the rabbits were exposed to doses of MSMA for a 24 hours period. The animals were observed for a period of 2 weeks for signs of toxicity following the exposure. The dermal LD/sub 50/ value was found to be between 2 and 4 g/kg.
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