Abstract
Langerhans cell histiocytosis (LCH) is a rare myeloid proliferative disorder characterized by abnormal proliferation of Langerhans cells, which can produce focal or systemic manifestations. Oral mucosa lesions of LCH are a diagnostic challenge, because of their destructive osteolytic character that could simulate other types of diseases in this region. Presently we report a regular case of LCH in a 12-year-old boy and an unusual one that presented concomitantly oral and skin lesions, in a 67-year-old woman. The two reported cases presented two different manifestations of this condition in different ages, showing the difficulty in general dentistry, mainly in pediatric and geriatric clinic that should considered LCH as differential diagnosis for the oral mucosa lesions with periodontal impairment.
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