ORAL AMYLOIDOSIS ASSOCIATED WITH MULTIPLE MYELOMA - A CASE REPORT

Abstract

A 54-year-old black female patient undergoing dexamethasone and bortezomib therapy for multiple myeloma presented with asymptomatic papules and nodules on the border of the tongue. The lesions were firm in consistency, with light yellowish color and ranging in size from 0.2 to 0.6 cm. A biopsy was performed, and the histopathologic examination with hematoxylin and eosin showed an extracellular deposition of eosinophilic material within the connective tissue. Congo red stain confirmed the diagnosis of amyloidosis. Amyloid deposition associated with multiple myeloma is progressive and can involve any organ. Currently, there is no treatment for this condition. Therefore, the patient has been kept under clinical follow-up showing involvement of the tongue, floor of the mouth, and lower and upper lip, which present with reduced tissue elasticity. A 54-year-old black female patient undergoing dexamethasone and bortezomib therapy for multiple myeloma presented with asymptomatic papules and nodules on the border of the tongue. The lesions were firm in consistency, with light yellowish color and ranging in size from 0.2 to 0.6 cm. A biopsy was performed, and the histopathologic examination with hematoxylin and eosin showed an extracellular deposition of eosinophilic material within the connective tissue. Congo red stain confirmed the diagnosis of amyloidosis. Amyloid deposition associated with multiple myeloma is progressive and can involve any organ. Currently, there is no treatment for this condition. Therefore, the patient has been kept under clinical follow-up showing involvement of the tongue, floor of the mouth, and lower and upper lip, which present with reduced tissue elasticity.