Abstract
Care for diabetic wounds remains a significant clinical problem. The present study was aimed at investigating the effect of skin gelatin from Chum Salmon on defective wound repair in the skin of diabetic rats. Full-thickness excisional skin wounds were made in 48 rats, of which 32 were diabetes. The diabetic rats were orally treated daily for 14 days with skin gelatin from Chum Salmon (2 g/kg) or its vehicle. Sixteen non-diabetic control rats received the same amount of water as vehicle-treated non-diabetic rats. Rats were killed to assess the rate of wound closure, microvessel density (MVD), vascular endothelial growth factor (VEGF), hydroxyproline (HP) contents in wound tissues and nitrate in plasma and wound tissue at 7 and 14 days after wounding. Skin gelatin-treated diabetic rats showed a better wound closure, increased MVD, VEGF, hyproxyproline and NO contents and a reduced extent of inflammatory response. All parameters were significant (P < 0.05) in comparison to vehicle-treated diabetic group. In light of our finding that skin gelatin of Chum Salmon promotes skin wound repair in diabetic rats, we propose that oral administration of Chum Salmon skin gelatin might be a beneficial method for treating wound disorders associated with diabetes.
Highlights
Chronic wound healing is a troublesome and common complication of diabetes, resulting in significant clinical morbidity, such as nonhealing ulcers, infection, gangrene and amputation [1,2].In recent years, treatment of diabetic wounds has intensified, but the amputation rate remains high and is associated with increased morbidity and mortality [3]
Diabetic rats of both the vehicle- and skin gelatin-treated groups weighed significantly less at the end of the experiment compared to the day of wounding
Despite reduction of body weight, no difference was observed between the vehicle- and skin gelatin-treated groups over the process of the experiment
Summary
Chronic wound healing is a troublesome and common complication of diabetes, resulting in significant clinical morbidity, such as nonhealing ulcers, infection, gangrene and amputation [1,2]. Treatment of diabetic wounds has intensified, but the amputation rate remains high and is associated with increased morbidity and mortality [3]. Care for diabetic wounds remains a significant clinical problem and the development of therapies that improve wound healing in diabetic patients is of critical importance. Due to toxicity or intolerance reactions in individual patients, therapeutic responses are limited in many diabetic patients despite the availability of new agents. There is growing interest in gelatin as a therapeutic agent of potential utility in the treatment of wound healing for a high level of safety and overall lack of toxicity.
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