Oral administration of resveratrol or lactic acid bacterium improves lens elasticity

Hayato Nagashima,Sachie Amano,Kazuo Tsubota,Motoshi Hayano,Nobunari Sasaki,Shigeru Nakamura

doi:10.1038/s41598-021-81748-w

Hayato Nagashima, Sachie Amano + Show 4 more

Open Access

https://doi.org/10.1038/s41598-021-81748-w

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Journal: Scientific Reports	Publication Date: Jan 26, 2021
Citations: 7	License type: open-access

Affiliation: Keio University

Abstract

A decrease in the elasticity of the ocular lens during aging is associated with loss of the accommodative ability of the eye, leading to presbyopia. Although near vision impairment is a social issue affecting the length of healthy life expectancy and productivity of elderly people, an effective treatment to improve near vision has not yet become available. Here we examined the effect of Enterococcus faecium WB2000, Lactobacillus pentosus TJ515, and resveratrol on lens elasticity in rats, where the stiffness of the ocular lens increases exponentially during the aging process. A combination of WB2000 and resveratrol improved lens elasticity not only in the long term but also with just short-term treatment. In addition, TJ515 decreased stiffness in the eye lens with long-term treatment. Therefore, the oral administration of WB2000 and resveratrol or TJ515 may be a potential approach for managing the progression of near vision impairment.

Highlights

A decrease in the elasticity of the ocular lens during aging is associated with loss of the accommodative ability of the eye, leading to presbyopia
The near vision impairment has an impact on a healthy life expectancy and work productivity, current treatments remain limited to wearing glasses or contact lenses and surgical intraocular lens insertion[2]
Considering the improvements in rat lens elasticity gained with long-term treatment with TJ515 alone or the combination of resveratrol and WB2000, we examined whether these supplements ameliorate the stiffness of the rat lens with only short-term treatment

Summary

Introduction

A decrease in the elasticity of the ocular lens during aging is associated with loss of the accommodative ability of the eye, leading to presbyopia. Given that protein synthesis and turnover are completely abolished in lens fiber cells, the maintenance of long-lived protein is crucial for continued lens homeostasis Posttranslational modifications, such as disulfide bonding, deamidation, glycation, and oxidation, are increased with age, with the greater rate of disulfide bond formation in α-, β-, and γ-crystallin capable of inducing the appearance of high-molecular-weight c rystalline[5,11,12,13,14,15,16]. Though resveratrol is known to prevent oxidative stress in human lens epithelial cells, its effects on lens stiffness and the progression of the near vision impairment remain unknown. The long-term administration of a lactic acid bacterium suppressed retinal inflammation and retinal cell loss in aged m ice[30]

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