Abstract
BackgroundTo evaluate the effect of oral Lactobacillus casei Shirota (LcS) administration on recovery of hand functions in senior patients diagnosed with an acute distal radius fracture.MethodsThis clinical trial is double-blind and placebo-controlled, in which 293 senior patients with distal radius fracture were initially enrolled. After exclusion, 264 eligible patients were randomly assigned to receive oral placebo or LcS daily for a period of 3 months after the fracture. Treatment outcomes were Michigan Hand Questionnaire (MHQ) score, radial deviation and inclination, and ulnar deviation and variance, all of which were monitored and measured every month.ResultsThroughout the length of this study, MHQ score, radial deviation and inclination, and ulnar deviation and variance of patients on oral LcS displayed a significantly faster improvement in comparison to those receiving placebo, over the 3-month intervention period.ConclusionOral administration of LcS dramatically accelerated hand function recovery in senior patients with distal radius fracture.
Highlights
Fracture of the distal radius is a most common upper extremity injury [1]
Every patient was instructed to consume 2 daily servings (100 mL per serving) of either skimmed milk that contains a minimum of 1.2 × 1010 colony-forming unit (CFU) Lactobacillus casei Shirota (LcS) or skimmed milk alone as the placebo
All patients were expected to consume 2 daily servings of either skimmed milk that contains a minimum of 1.2 × 1010 colony-forming unit (CFU) LcS or identical skimmed milk alone as the placebo, with one serving at breakfast and the other at dinner, for 3 months since the day after the fracture
Summary
Fracture of the distal radius is a most common upper extremity injury [1]. the epidemiology of forearm fracture does not display an age-dependent exponential increase like those of the hip or the spine, as a result of age-associated increase in osteoporosis incidences as well as decrease of bone mass acquisition, the senior population is more likely to suffer acute distal radius fractures and prone to slower healing processes [2, 3].Probiotics, which are live microbial dietary ingredients, have been shown to exert several health benefits [4, 5].Consumption of probiotics, often as dietary supplement in drinks or capsules, is clinically safe as confirmed in patients with various diseases [6,7,8], such as children who are severely ill [9] or professional athletes [10]. Valyl-prolyl-proline is a bioactive peptide produced from fermentation with Lactobacillus helveticus and has been demonstrated to enhance bone formation in vitro [14]. It has been consistently shown in various animal models that probiotic treatment prevents loss of bone mass and increases bone mass density [15,16,17]. To evaluate the effect of oral Lactobacillus casei Shirota (LcS) administration on recovery of hand functions in senior patients diagnosed with an acute distal radius fracture
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