Abstract
Oral administration of gamma-aminobutyric acid affects heat production in a hot environment in resting humans
Highlights
Central administration of g-amino butyric acid (GABA) induces lower body temperature in animals in hot ambient air
On the basis of a previous study conducted in our laboratory, we have reported that oral GABA administration might induce lower core temperature during rest under a hot environment [12]
We hypothesized that systemic administration of GABA in humans would induce hypothermia in a hot environment and that this response would be observed in association with decreased heat production
Summary
Eight male participants drank a 200-ml sports drink with 1 g of GABA (trial G) or without GABA (trial C), rested for 30 minutes in a sitting position in a hot environment (ambient air temperature 33°C, relative humidity 50%). Participants Eight healthy nonsmoking men who usually exercised 3 to 5 days per week were included in this study. Their physical characteristics were age 23.5 ± 3.6 years, height 172.6 ± 3.5 cm, weight 66.9 ± 7.4 kg, body mass index 22.5 ± 2.7 kg/m2 (all means ± SD). The dose was the maximal consumption of GABA for a single ingestion (Japan Standard Commodity Classification 872199). Both the placebo and the GABA drink were stored at room temperature controlled at 23°C to 25°C. The sports drink (200 ml) provided 30 kcal of energy, 7.4 g of carbohydrate, 0 g of protein and 0 g of fat
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