Abstract
We investigated on how to effectively administer orally factor VIII preparation to two patients with von Willebrand's disease as volunteers, and the following results were obtained: (1) Bleeding time and aPTT were shortened, but no change of PT was observed. (2) Factor VIII:C increased slightly, but no significant increase was observed in factor VIIIC:Ag. The recovery of factor VIII:C was 19–40 %. (3) Factor VIIIR:Ag increased slightly, but no changes of factor VIIIR:RCo were observed. (4) In the Ristocetin induced platelet aggregation ( 1.5 mg/ml of ristocetin), the collected aggregabilities were not clear. The factor VIII concentrate preparations, entrapped with liposome, were absorbed from the intestines.
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