Abstract
BackgroundProbiotic bacteria can induce immune regulation or immune tolerance in patients with allergic diseases, but the underlying mechanisms are still unclear. There has been a growing interest in the use of beneficial bacteria for allergic diseases recently. This study aimed at exploring whether Clostridium butyricum CGMCC0313-1 (C. butyricum) can reduce β-lactoglobulin(BLG)-induced intestinal anaphylaxis in a murine model of food allergy.MethodsThe preventive and therapeutic effects of oral C. butyricum on anaphylactic symptoms induced via BLG in food allergy mice were investigated. Intestinal anaphylaxis, T helper (Th)-specific cytokines and transcription factors, secretory IgA (sIgA), CD4+ CD25+ Foxp3Treg cell and histopathological alterations were examined.ResultsClostridium butyricum significantly ameliorated intestinal anaphylaxis symptoms in the food allergy mice. sIgA and CD4+ CD25+ Foxp3Treg cell were increased by oral C. butyricum. It also reversed the imbalance of Th1/Th2 andTh17/Treg.ConclusionsClostridium butyricum reduces BLG-induced intestinal anaphylaxis in mice and might be an additional or supplementary therapy for food allergy.
Highlights
Probiotic bacteria can induce immune regulation or immune tolerance in patients with allergic diseases, but the underlying mechanisms are still unclear
This study aimed to explore whether oral C. butyricum can reduce food allergy in mice
Clostridium butyricum ingestion inhibits the development of intestinal anaphylaxis Oral challenges with BLG in sensitized mice lead to increasing severity of diarrhea and anaphylaxis, and a robust increase in circulating mouse mast cell protease 1 (mMCP-1)
Summary
Probiotic bacteria can induce immune regulation or immune tolerance in patients with allergic diseases, but the underlying mechanisms are still unclear. This study aimed at exploring whether Clostridium butyricum CGMCC0313-1 (C. butyricum) can reduce β-lactoglobulin(BLG)-induced intestinal anaphylaxis in a murine model of food allergy. Food is a foreign antigen that is necessary for nutrition. Food antigens present a continuous challenge throughout life. Humans have adapted to food via mechanisms of immune tolerance. Food allergy is defined as abnormal immune responses resulting from breakdown of natural oral tolerance [1]. Food allergy is an increasing public health problem worldwide [2,3,4,5] and has been estimated to affect approximately 5% of adults and 8% of children [6].
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