Abstract
Background: This study examined the acute and sub-acute toxic effects of Terminalia chebula and Achillea wilhelmsii extracts on the murine model.Methods: In both phases, mice were assigned to intervention and control groups. At the end of study, the liver, kidney, and heart tissues were collected for histopathological studies.Results: In the acute phase of the study, the safe dose was ≤5000 mg/kg for both extracts. In sub-acute phase, LD50 (95% CI) of Achillea wilhelmsii extract was determined ≥5000 mg/kg and that of Terminalia chebula extract 2754.436 (2438-3114) mg/kg. The highest dose of T. chebula extract induced few histopathological changes.Conclusion: It will be useful to gain information on the minimum lethal doses of T. chebula and A. wilhelmsii to adopt safe doses of the two plants.
Highlights
Nowadays, due to the increasing use of medicinal herbs to treat various diseases, the study of the therapeutic and negative effects of these drugs has attracted the attention of researchers
The total phenolic contents of the T. chebula and A. wilhelmsii extracts were calculated at 276.66 ± 1.45 mg gallic acid equivalent (GAE)/g, 55.07 ± 0.295 mg GAE/g dry extract, respectively
The results showed that the antioxidant capacity of T. chebula was 6.85 times more than butylated hydroxytoluene (BHT) and this capacity for A. wilhelmsii was 0.21 time more than BHT
Summary
Due to the increasing use of medicinal herbs to treat various diseases, the study of the therapeutic and negative effects of these drugs has attracted the attention of researchers. In most studies that have been conducted on toxicity rate of medicinal agents in laboratory animals, test agents are inoculated orally. Studies in this area are important with respect to drugs, foods, and accidental poisoning [3, 4]. As no study has yet been conducted on the subacute and acute toxicity of Terminalia chebula Retz and Achillea wilhelmsii, the study was aimed to investigate these aspects of the extracts. This study examined the acute and sub-acute toxic effects of Terminalia chebula and Achillea wilhelmsii extracts on the murine model. Conclusion: It will be useful to gain information on the minimum lethal doses of T. chebula and A. wilhelmsii to adopt safe doses of the two plants
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