Oral Absorption with Various Preparations of Spironolactone in Dogs

Abstract

Gastrointestinal absorption of various spironolactone preparations was investigated in acute tests with dogs treated with an aldosterone-like steroid. Absorption was determined by the appearance in plasma of aldadiene, a major spironolactone metabolite with fluorogenic properties, and by renal manifestations of mineralocorticoid antagonism. Variable absorption was noted with tablet forms of spironolactone with particle size controlled to suggest a profound influence of pharmaceutical formulation. Available data would indicate that the assay using dogs is valuable for clinical prediction of absorption differences between spironolactone preparations. Gastrointestinal absorption of various spironolactone preparations was investigated in acute tests with dogs treated with an aldosterone-like steroid. Absorption was determined by the appearance in plasma of aldadiene, a major spironolactone metabolite with fluorogenic properties, and by renal manifestations of mineralocorticoid antagonism. Variable absorption was noted with tablet forms of spironolactone with particle size controlled to suggest a profound influence of pharmaceutical formulation. Available data would indicate that the assay using dogs is valuable for clinical prediction of absorption differences between spironolactone preparations.